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Comparative Effectiveness of Antipsychotic Medications in Patients With Schizophrenia (CATIE Schizophrenia Trial)

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Trial Conditions
  • Schizophrenia
What is the purpose of this trial?

The CATIE Schizophrenia Trial is part of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Project. The schizophrenia trial is being conducted to determine the long-term effects and usefulness of antipsychotic medications in persons with schizophrenia. It is designed for people with schizophrenia who may benefit from a medication change. The study involves the newer atypical antipsychotics (olanzapine, quetiapine, risperidone, clozapine, and ziprasidone)and the typical antipsychotics (perphenazine and fluphenazine decanoate). All participants will receive an initial comprehensive medical and psychiatric evaluation and will be closely followed throughout the study. For most participants the study will last up to 18 months. Everyone in the study will be offered an educational program about schizophrenia and family members will be encouraged to participate.

Date & Status

Completed

Who can Participate?

Eligibility

Ages:
18  - 65 

Gender:
Both

Eligibility

Inclusion

- 18-65 years old

- DSM-IV diagnosis of schizophrenia

- adequate capacity to consent

Exclusion

- Intolerance or failure to respond to one of the treatments

- Diagnoses of schizoaffective disorder, mental retardation, pervasive developmental
disorder, delirium, dementia, amnesia

- First episode of schizophrenia

- Women currently pregnant or breast-feeding

Gender: Both
Steward Physician(s)
  • Jeffrey A Lieberman, MD
Trial Interventions
Drug
  • perphenazine
  • olanzapine
  • quetiapine
  • risperidone
  • ziprasidone
  • clozapine
  • fluphenazine decanoate
Physician Researcher

Investigator Name:

  • Jeffrey A Lieberman, MD

Other Information

Sponsor: National Institute of Mental Health (NIMH)
Phase: Phase 4
Trial ID: NCT00014001
Volunteers:  Not Accepting Healthy Volunteers

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