500 Boylston Street, Boston, MA 02116 617-419-4700
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The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is
to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the
traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment
of carotid artery stenosis to prevent recurrent strokes in those patients who have had a TIA
(transient ischemic attack) or a mild stroke within the past 6 months (symptomatic) and in
those patients who have not had any symptoms within the past 6 months (asymptomatic).
Active, not recruiting
Ages:18 and older
Inclusion Criteria: - Symptomatic patients with recent neurological events (TIA or non-disabling stroke) with an associated carotid stenosis greater than or equal to 50% by angiography or greater than or equal to 70% by ultrasound or greater than or equal to 70% by CTA or MRA are eligible for randomization. - Asymptomatic patients with no recent (in the last 6 months) neurological events referable to the study with artery and carotid stenosis (patients with symptoms beyond 180 days are considered asymptomatic) greater than or equal to 60% by angiography or greater than or equal to 70% by ultrasound or greater than or equal to 80% by CTA or MRA are eligible for randomization. Exclusion Criteria: - Conditions that: (1) interfere with the evaluation of endpoints, (2) are known to interfere with the completion of CEA or CAS, or (3) affect the likelihood of survival for the study period (4 years). Chronic atrial fibrillation and/or anti-coagulation or episodic atrial fibrillation within the last 6 months.
Sponsor: University of Medicine and Dentistry New Jersey
Phase: Phase 3
Trial ID: NCT00004732
Not Accepting Healthy Volunteers