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Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

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Trial Conditions
  • Atherosclerosis
  • Stroke
  • Carotid Stenosis
  • Cerebral Infarction
  • Myocardial Infarction
What is the purpose of this trial?

The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of carotid endarterectomy (CEA) for the treatment of carotid artery stenosis to prevent recurrent strokes in those patients who have had a TIA (transient ischemic attack) or a mild stroke within the past 6 months (symptomatic) and in those patients who have not had any symptoms within the past 6 months (asymptomatic).

Date & Status

Active, not recruiting

Who can Participate?

Eligibility

Ages:
18 and older

Gender:
Both

Eligibility

Inclusion Criteria:

- Symptomatic patients with recent neurological events (TIA or non-disabling stroke)
with an associated carotid stenosis greater than or equal to 50% by angiography or
greater than or equal to 70% by ultrasound or greater than or equal to 70% by CTA or
MRA are eligible for randomization.

- Asymptomatic patients with no recent (in the last 6 months) neurological events
referable to the study with artery and carotid stenosis (patients with symptoms
beyond 180 days are considered asymptomatic) greater than or equal to 60% by
angiography or greater than or equal to 70% by ultrasound or greater than or equal to
80% by CTA or MRA are eligible for randomization.

Exclusion Criteria:

- Conditions that: (1) interfere with the evaluation of endpoints, (2) are known to
interfere with the completion of CEA or CAS, or (3) affect the likelihood of survival
for the study period (4 years). Chronic atrial fibrillation and/or anti-coagulation
or episodic atrial fibrillation within the last 6 months.

Gender: Both
Steward Physician(s)
  • Thomas G. Brott, M.D.
Trial Interventions
Device
  • Carotid Artery Stenting (CAS)
Procedure
  • Carotid Endarterectomy (CEA)
Physician Researcher

Investigator Name:

  • Thomas G. Brott, M.D.

Other Information

Sponsor: University of Medicine and Dentistry New Jersey
Phase: Phase 3
Trial ID: NCT00004732
Volunteers:  Not Accepting Healthy Volunteers

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