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Randomized, Open Label, Phase III Trial Of CP- 751,871 In Combination With Paclitaxel And Carboplatin Versus Paclitaxel And Carboplatin In Patients With Non Small Cell Lung Cancer

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Trial Conditions
  • Carcinoma, Squamous Cell
  • Carcinoma, Adenosquamous
  • Carcinoma, Large Cell
  • Carcinoma, Non-Small-Cell Lung
What is the purpose of this trial?

Determine whether the addition of CP- 751,871 in combination with paclitaxel plus carboplatin prolongs survival in patients with locally advanced (Stage IIIB with pleural effusion) or metastatic (Stage IV or recurrent) NSCLC of non adenocarcinoma histology.

Date & Status


Who can Participate?


18 and older



Inclusion Criteria:

- Confirmed diagnosis of non small cell lung cancer with a primary histology of
predominantly squamous cell, large cell or adenosquamous carcinoma.

- Advanced NSCLC with documented Stage IIIB (with pleural effusion) or Stage IV or
recurrent disease.

- No prior systemic treatment for NSCLC, except for adjuvant chemotherapy. Adjuvant
chemotherapy must have completed for greater than or equal to 12 months prior to

- Prior surgery or radiation therapy is permitted if completed at least 3 weeks prior
to randomization and all acute toxicities have resolved.

- ECOG performance status (PS) 0 or 1.

Exclusion Criteria:

- Patients with symptomatic central nervous system (CNS) metastases are not permitted.

- Patients requiring chronic steroid use or patients with uncontrolled diabetes are not

- Patients with other active cancer types are not permitted.

Gender: Both
Steward Physician(s)
  • Pfizer Call Center
Trial Interventions
  • CP-751,871 (Figitumumab)
  • Carboplatin
  • Paclitaxel
  • Carboplatin
  • Paclitaxel
Physician Researcher

Investigator Name:

  • Pfizer Call Center

Other Information

Sponsor: Pfizer
Phase: Phase 3
Trial ID: NCT00596830
Volunteers:  Not Accepting Healthy Volunteers

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